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pentobarbital will decrease the level or result of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with strong CYP3A4 inducers lowers plasma focus of abemaciclib and its metabolites.The impact of the resultant lessened blood amounts of griseofulvin on therapeutic